Two people were killed and two more wounded when a small plane crashed into the dangers, an ambulance confirmed.
The plane descended on the busy Avenue Marques de Sao Vicente, faced with the bus on the ground.
The passenger on the bus and motorcyclist suffered from garbage to the hospital, while those who died were aboard the plane, said Maikon Cristo Fire Service.
The smoke could be seen as it rises above Brazil’s largest city after the incident.