Paramedic Magen David Adom Avichai Ben Tsurya described it as “a very serious attack that spread along the road involving several vehicles.”
“We conducted a quick search and identified two women and a man in private vehicles with no pulse, suffering from serious gunshot wounds. We had no choice but to declare them dead on the spot,” he said in a statement.
“Inside the bus, we treated victims of gunshots and broken windows, including the bus driver, who was conscious and suffered gunshot wounds, and other victims in a mild to moderate condition.”
The wounded were evacuated to two hospitals in the center of Israel.
The Israeli police later named the man killed as Sergeant Elad Yaakov Winkelstein, a police investigator from Kibbutz Ein Hanatziv in northern Israel who worked in the West Bank settlement of Ariel.
Israeli Prime Minister Benjamin Netanyahu vowed to bring to justice what he called “heinous killers” and anyone who helped them.
“No one will leave,” he wrote on X.
There were no immediate claims from Palestinian armed groups, although Hamas hailed the attack as a “heroic response against (Israel’s) ongoing crimes, including the war in Gaza.”
Hundreds of Palestinians and dozens of Israelis have been killed in a surge of violence in the West Bank since the start of the war, which was sparked by a deadly attack by Hamas in southern Israel on October 7, 2023.
On Sunday, the Palestinian Ministry of Health said that two Palestinians – a 17-year-old boy and a 40-year-old man – were killed by Israeli forces in the West Bank.
The teenager was shot dead during an Israeli raid on the Askar refugee camp near the city of Nablus, which is 10 km (6 miles) east of Al-Funduk, the report said.
The Israeli military said that its troops fired at people who threw explosives at them in the Nablus area, according to Reuters. It added that “the impact has been identified” and that the incident is under review.
The man was killed in the town of Meitaloon, 21 km northeast of al-Funduk, where the Israeli military said Border Police officers killed an armed suspect in a wider operation that also arrested 19 others.
