The Chinese Air Force launched rescue operations and sent drones to the affected area, which is at the foot of Mount Everest and where temperatures are well below zero.
Electricity and water are cut off in the region.
Chinese President Xi Jinping also called for comprehensive search and rescue efforts to minimize casualties and relocate affected residents.
While tremors were felt in Nepal, no damage or casualties were reported, a local official in Nepal’s Namche region, near Mount Everest, told AFP.
The edge that lies next to it the main fault of the Indian and Eurasian tectonic plates, is a place of frequent seismic activity. In 2015, a 7.8-magnitude earthquake near Kathmandu, the capital of Nepal, killed nearly 9,000 people and injured more than 20,000.