Manipulating a type of neuron can facilitate facilitates
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Mouse brain neurons tell them when they had enough food, because people will probably have the same cells, we could one day manipulate to help treat obesity.
“We wanted to answer the main question to how the brain felt and responds to different signals,” says Alexander Nectow Columbia University in New York.
To find out more, he and his colleagues used a different kind of molecular profile to distinguish different cabin Types in mice brains. In the dorsal raphe core – Eating, including humor and sleep, a part of the brain associated with functions – they found cells that create a hormone called Cholecystokinin, which help regulate hunger.
To study what these cells play the action, researchers measured their activity about their day around his day. “Every time the animals went in search of food bite, the activity turned on and then eliminated,” he says ntwow. “These live neurons are smell and things like food, the taste of food, because of the neuronal hormones that are released to the intestinal food sensation and intestinal food, and that information has been taken advantage of.”
The researchers then used a technique called opogenetics, which leads to the neuron engineering that can turn on and off with light. When they used light, to activate them, mice slowed down their food. The more intense activation, the faster the animals slowed down and then stopped.
Because neurons are sitting in the brain, the characteristic of ancestors similar to the vertebrates, we think we probably think that Neckow. “If we didn’t confirm both, I think humans have these neurons, no doubt.”
The group also has found that mouse neurons could be activated by a compound called glucog (GLP-1) agonista, obesity and 2. A type of drug type 2. diabetesThe most popular semagluturo is sold under the name of brands like Ozempic and Wegoy.
If these neurons have the same function of people, we could control the customs of eating properly in theory, whether to combine with obese-based drugs or this approach Weight lossHe said ntwow.
“Understanding the circuit ruled by the leaving to eat is especially important in almost ubiquitous food availability,” he says Jeff Davies Swansea University, United Kingdom. “The authors used an elegant method to identify these important cell populations.”
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