Black women in the US are about 40 percent Killing the Chest Canceversatile Twice as white women to be diagnosed with breast cancer Before 40 years.
The difference is added to the worrying tendency of women who are diagnosed with increasingly diagnosing breast cancer, adul and middle-aged in general 2025 shows annual cancer annual cancer report.
Differences of health and revenue in the disproportional rates that die from breast cancer. But genetics also play an important role. In recent years, more researchers have joined black women to kill breast cancer more than any other breed group, having more aggressive tumors and developing breast cancer. a slightly lower in general incidence Breast cancer than white women.
To help Science Journalism
If you enjoy this article, consider entering award-winning journalism Subscribe. By purchasing subscription, you are helping to ensure the future of stories about the discoveries and ideas that are conformed to today.
More than 86 percent The DNA samples of genomics studies are participants with European ancestors, and from 2016 to 2021, the proportion of samples of non-populations were equal or decreased. Humans are 99.9 percent genetically equal, but the small level of difference between each other has emphasized the effects of cancer and other diseases.
Some genetic variants or mutations are often associated with ancestors, and some have been connected to poor health results. Variation hammer can affect the risk of cancer in genes that maintain inflammation and cell division. For example, variants that turn off Krca1 and Brca2 The tumor’s suppressor genes are associated with the more incidence of breast cancer in the women of Jewish Ashkenazi.
On the contrary, nothing is known for black women because of genetic variants in danger of cancer One of the greatest international collaborations In the study of breast cancer inequality.
“Group groups that have learned to identify genetic risk markers have largely been European descendants,” says Davis. “This means that the genetic risk that exists in other groups is unnoticed, that it has been documented, but we know that it exists.”
Researchers have more people with ancestors of African ancestors have identified more variants that could affect the survival of genomic studies and breast cancer. And scientists are internationally involved in sharing data, including DNA stores and other resources for more discoveries that can improve the treatment of population cancer.
Why breast cancer is deadly in black women
Breast Cancer Death declines For all groups of 1990. Except for American women since the year, but the gap of survival spread among black and white women.
The extensive use of mammograms, along with the implementation of hormone therapies more than 40 years, has significantly decline in death rates. But still Black women are a little more To receive regular mammograms than white women, hormone therapy is so effective for black women.
“Before the 1980s, it doesn’t matter if you are black or white, I would like it The same chance to survive breast cancer“Davis says.
He and other scientists struck Genetics for the reasons for black women and younger cancer reasons and reasons with more aggressive tumors.
In the early 2000s, scientists were missing three recipients who respond to hormone therapies in hormone therapies and called the understore of this cancer in the negative breast cancer (TNBC). Black women are twice twice to develop this type of cancer: the main assistant of mortality. Davis was one of the first researchers who worked behind the genetic mechanisms behind negative breast cancer.
“We started asking the question,” What do white women have in common? “Davis says.” That said to the ancestors of Africa directly. “
The former scientific director of the Davis International Center to study the subpotypes of breast cancer. It is one of the great international research to study the genetic differences in breast cancer in women with ancestors. Weill Cornell’s Main Researcher and Breast Surgeon of Lisa Newman, Researcher and the main surgeon, were among the first researchers who observed most cases of TNBC. Most African Americans have ancestors of West African Saharan.
By working with Ghanaian and Ethiopian organizations, Davis and Newman created a more inclusive image of man’s genome, mapping the genetic profiles of people with ancestors of Africa using African Americans and African tissues.
Research by Davis has found that African American women were much more than white women aggressive, androgen receiver-negative subtip tnbc. And 2022 Exam Davis has shown the higher amount of quantifiable ancestors of Africa: that the self-reported independent race was a DNA measurement – it was linked to a larger number of immunological cells in black women with TNBC. But these anti-cancer cells were turned on.
The discovery can report Development of TNBC immunothies It may be more effective for black women, personalized with the characteristics of the tumor that do not currently have a therapeutic, with Davis and Medical Medicine school colleagues. “The arrival of each new technology or treatment protocol has expanded differences in population mines,” they added.
Trace genetic hazards
Scientists have found gene sides of people with people in African ancestors, including a protection against malaria.
Davis and other researchers found a Gene call variant Aware-Harra controls, by a key driver of cancer, causes genes at lower levels with ancestors in West Africa in Saharan. Aware It is expressed in red blood cells and tumors. In red blood cells, Aware It creates protein that rugged parasites can invade.
Low Aware The expression of people with ancestors of African ancestors of Sahara was evolving selective because Malaria is endemic in the region. But there is a lower level of disadvantage Aware Tumors is associated with reduced cancer survivors .davis presented the patent Measurement test Aware expressionDeveloping, it can help determine the plans for treating black women cancer.
In addition to Darc, researchers are studying how they are looking at the Supressor genes of the BRCA1 and BRCA2 tumor. Multiple variants Krca1 and Brca2 Tumor’s suppressor genes dominated black women with breast cancer in Florida, according to A Analysis by researchers by researchers at the University of Florida. The authors of the study suggested that it may benefit from black women who develop breast cancer in 50 years or younger Brca Screening.
And in the genetic consortia of the breast cancer of the African ancestor cancer, Vanderbilt is aimed at University Medical Centers, Published findings Finally, from what they said, perhaps, is the greatest study of women with African ancestors for breast cancer. More than 40,000 women from various African countries, Barbados and 40,000 US data collected data, identified 12 variants associated with breast cancer in women with ancestors of Africa. Were tied with three Tnbc.
Introduce progressive research practices, such as research cohorts, exacerbate genetic research on the national health institutes, says Bretain Jenkins-Mr. Johns Hopkins Bloomberg Public Health School.
“All research (nih-funded) is all believed to be Fair (Find, interactive and reusable), “says Jenkins-Lord.” In the past, you should contact researchers and ask for data, “he / she didn’t want to give it, and if you are a competitor, maybe not are “.
Knowledge of more genetic variants The black women help assess the individual risk of their cancer, says Altovise Ewing-Crawford, a genetic health heritage of Genentech. Doctors are less likely to recommend black patients for genetic tests due to the lack of information on variants in favor of African ancestors. Ewing-Crawford suffers from the genetic tests, because the scientists are constantly found in a variety of unchangeable.
“Genomic research is growing and prioritize the findings of genetic variants … Assorted populations, we can see that the benefits of the genetic test are more recent way,” said Ewing-Crawford.
Other cancer risk factors
Researchers have begun to understand how genetics interact with health-free factors, such as racism and environmental risks to achieve the risk of death of breast cancer. “It is probably about making connections between environmental exposure and cancer in a century,” said Jenkins-Lord, the author of this article said in an interview in an interview Hopkins Bloomberg Public Health Journal. “You have your risk, you have your result, but in the middle, you have everything happening.”
Jenkins-Mr. and other researchers are learning the epigenics of urban populations due to additional approaches due to ideal subjects, income and diversity. In Baltimore, when Jenkins-Lord works, they are mostly white cheswold and nice and indirect neighborhood neighborhoods 1And-Year-longer life expectancy Mostly parts of the black neighborhood and druid heights, is partly a division related to cancer results.
In black women who lived in Baltimore neighborhoods, the Jenkins-Lord found The key tumor was indicated at lower levels of suppressor geneBut the genes did not affect the white women who live in the same neighborhoods. “Genetics contribution We are looking at the expression of this tumor (and) We know that the environment is helping in some way,” Jenkins- Lord.
In the Atlanta Metropolitan area, Jasmine Miller-Kleinhenz, the cervical biologist of the University of Mississippi, found a systematic denial of the systematic denial of breast cancer in areas of contemporary rounding or mortgage loans based on a location demographic. A quick biological aging. “It is important because cancer mainly aging cell disease,” says Miller-Kleinhenz. In the study, nearly 90% of black women in the study comparing about 30 percent of white women living in areas.
Links on breast cancer differences link data on socio-economic characteristics, genetic ancestry and gene expression, with health result, Jenkins-Lord. “It’s a gene-versus environment question, and I think this research will continue,” he explains. “Your genetics … they will affect, but they will live in the expression of these genes related to cancer throughout your life.”
